Io in Humanitas
Unità
Sezione di Oncologia medica universitaria | UO Oncologia Medica e Oncoematologia
Ruolo in Ospedale
Medico Specialista in Oncologia Medica
Specializzazione
Oncologia Medica
Aree mediche di interesse
Carcinoma mammario, neoplasie ginecologiche, ricerca in oncologia
Esperienze precedenti
Marzo 2023 – In corso
Ricercatore Universitario di tipo A
Dipartimento di Medicina Clinica e Sperimentale
Università di Catania
Formazione
Laurea
Laurea in Medicina e Chirurgia
Anno di laurea: 2015
Università degli Studi di Catania
Specializzazione
Oncologia Medica
Anno: 2020
Università degli Studi di Messina
Maggio 2022 – In corso
Global Clinical Scholarship Research Training
Harvard Medical School
Novembre 2019 – Gennaio 2023
Dottorato di Ricerca Internazionale in Biomedicina Traslazionale
Università di Catania, Dipartimento di Medicina Clinica e Sperimentale
Novembre 2019 – Ottobre 2020
Clinical Research Fellowship
Istituto Oncologico della Svizzera Italiana, Unità di Sviluppo di Nuovi Farmaci – Bellinzona (CH)
Dicembre 2012 – Marzo 2015
Tirocinio in Oncologia Medica
Pubblicazioni ed attività scientifica
- Motta L, Puglisi M, Pavone G, Motta G, Martorana F, Bambaci M, et al. Unveiling Prostate-Specific Membrane Antigen’s Potential in Breast Cancer Management. Cancers. 2025;17.
- Massimino M, Tirrò E, Stella S, Tomarchio C, Di Bella S, Vitale SR, et al. An Optimized NGS Workflow Defines Genetically Based Prognostic Categories for Patients with Uveal Melanoma. Biomolecules. 2025;15.
- Martorana F, Pavone G, Sessa C, Treglia G, Lheureux S, Colombo I. Can we learn from failures? A systematic review of phase III trials in platinum-resistant ovarian cancer. International Journal of Gynecological Cancer. 2025;35.
- Catanuto G, Gentile D, Martorana F, Tomatis M, Ponti A, Marotti L, et al. Clinico-pathological features predicting indication to mastectomy in breast cancer patients achieving complete response after neoadjuvant therapy: A retrospective analysis of the EUSOMA database. European Journal of Surgical Oncology. 2025;51.
- Caltavituro A, Buonaiuto R, Salomone F, Pecoraro G, Martorana F, Lauro VD, et al. Warming-up the immune cell engagers (ICEs) era in breast cancer: state of the art and future directions. Critical Reviews in Oncology/Hematology. 2025;206.
- Stella S, Vitale SR, Massimino M, Martorana F, Tornabene I, Tomarchio C, et al. In Silico Prediction of BRCA1 and BRCA2 Variants with Conflicting Clinical Interpretation in a Cohort of Breast Cancer Patients. Genes. 2024;15.
- Piazza D, Martorana F, Curaba A, Sambataro D, Valerio MR, Firenze A, et al. The Consistency and Quality of ChatGPT Responses Compared to Clinical Guidelines for Ovarian Cancer: A Delphi Approach. Current Oncology. 2024;31:2796-804.
- Pavone G, Marino A, Fisicaro V, Motta L, Spata A, Martorana F, et al. Entangled Connections: HIV and HPV Interplay in Cervical Cancer—A Comprehensive Review. International Journal of Molecular Sciences. 2024;25.
- Nucera S, Conti C, Martorana F, Wilson B, Genta S. Antibody-Drug Conjugates to Promote Immune Surveillance: Lessons Learned from Breast Cancer. Biomedicines. 2024;12.
- Martorana F, Scandurra G, Valerio MR, Cufari S, Vigneri P, Sanò MV, et al. A review and metanalysis of metronomic oral single-agent cyclophosphamide for treating advanced ovarian carcinoma in the era of precision medicine. Journal of Oncology Pharmacy Practice. 2024;30:173-81.
- Martorana F, Sanò MV, Valerio MR, Fogli S, Vigneri P, Danesi R, et al. Abemaciclib pharmacology and interactions in the treatment of HR+/HER2− breast cancer: a critical review. Therapeutic Advances in Drug Safety. 2024;15.
- Marino A, Pavone G, Martorana F, Fisicaro V, Motta L, Spampinato S, et al. Navigating the Nexus: HIV and Breast Cancer—A Critical Review. International Journal of Molecular Sciences. 2024;25.
- Gori S, De Rose F, Ferro A, Fabi A, Angiolini C, Azzarello G, et al. Follow-up of early breast cancer in a public health system: A 2024 AIGOM consensus project. Cancer Treatment Reviews. 2024;131.
- Gentile D, Martorana F, Karakatsanis A, Caruso F, Caruso M, Castiglione G, et al. Predictors of mastectomy in breast cancer patients with complete remission of primary tumor after neoadjuvant therapy: A retrospective study. European Journal of Surgical Oncology. 2024;50.
- Gebbia V, Martorana F, Scandurra G, Valerio MR, Cufari S, Vigneri P, et al. A retrospective, real-life analysis of metronomic oral single-agent cyclophosphamide for the treatment of platinum-pretreated advanced ovarian carcinoma in Italy. Journal of Oncology Pharmacy Practice. 2024;30:853-9.
- Di Grazia G, Conti C, Nucera S, Motta G, Martorana F, Stella S, et al. REThinking the role of the RET oncogene in breast cancer. Frontiers in Oncology. 2024;14.
- Di Benedetto G, Barca I, De Gregorio L, Scollo C, Gianì F, Martorana F, et al. Medullary thyroid cancer in MEN2 pediatric/adolescent carriers of RET mutation: genotype/phenotype correlation and outcome in a retrospective series of 23 patients. Frontiers in Oncology. 2024;14.
- Conti C, Nucera S, Di Grazia G, Martorana F, Motta F, Vigneri P, et al. Nasopharyngeal Metastasis from Lung Adenocarcinoma: A Case Report and Literature Review. Case Reports in Oncology. 2024;17:1358-65.
- Stella S, Massimino M, Manzella L, Parrinello NL, Vitale SR, Martorana F, et al. Glucose-dependent effect of insulin receptor isoforms on tamoxifen antitumor activity in estrogen receptor-positive breast cancer cells. Frontiers in Endocrinology. 2023;14.
- Stella S, Martorana F, Massimino M, Vitale SR, Manzella L, Vigneri P. Potential Therapeutic Targets for Luminal Androgen Receptor Breast Cancer: What We Know so Far. OncoTargets and Therapy. 2023;16:235-47.
- Massimino M, Martorana F, Stella S, Vitale SR, Tomarchio C, Manzella L, et al. Single-Cell Analysis in the Omics Era: Technologies and Applications in Cancer. Genes. 2023;14.
- Martorana F, Di Grazia G, Rosano GN, Vecchio GM, Conti C, Nucera S, et al. More Than Meets the Eye: A Case of Breast Cancer Switching from Being Luminal-Androgen-Receptor-Positive to Being Hormone-Receptor-Positive. Medicina (Lithuania). 2023;59.
- Gebbia V, Valerio MR, Martorana F, Sanò MV, Vigneri P. Letter to the Editor: statistics and clinical perception of patients’ reported outcomes for palbociclib and abemaciclib: a sliding doors story. Journal of Comparative Effectiveness Research. 2023;12.
- Gebbia V, Martorana F, Sanò MV, Valerio MR, Giotta F, Spada M, et al. Abemaciclib-associated Diarrhea: An Exploratory Analysis of Real-life Data. Anticancer Research. 2023;43:1291-9.
- Tirrò E, Martorana F, Micale G, Inzerilli N, Carciotto R, Romano C, et al. Next generation sequencing in a cohort of patients with rare sarcoma histotypes: A single institution experience. Pathology Research and Practice. 2022;232.
- Stella S, Vitale SR, Massimino M, Motta G, Longhitano C, Lanzafame K, et al. Molecular Analysis of Luminal Androgen Receptor Reveals Activated Pathways and Potential Therapeutic Targets in Breast Cancer. Cancer Genomics and Proteomics. 2022;19:464-76.
- Stella S, Vitale SR, Martorana F, Massimino M, Pavone G, Lanzafame K, et al. Mutational Analysis of BRCA1 and BRCA2 Genes in Breast Cancer Patients from Eastern Sicily. Cancer Management and Research. 2022;14:1341-52.
- Sapuppo G, Martorana F, Tirrò E, Moli RL, Masucci R, Baldeschi L, et al. Orbital metastasis from thyroid cancer: a case report and review of the literature. Annals of Palliative Medicine. 2022;11:3346-55.
- Sanò MV, Martorana F, Lavenia G, Rossello R, Prestifilippo A, Sava S, et al. Ribociclib efficacy in special populations and analysis of patient-reported outcomes in the MONALEESA trials. Expert Review of Anticancer Therapy. 2022;22:343-51.
- Pavone G, Romano C, Martorana F, Motta L, Salvatorelli L, Zanghì AM, et al. Giant Paratesticular Liposarcoma: Molecular Characterization and Management Principles with a Review of the Literature. Diagnostics. 2022;12.
- Martorana F, Da Silva LA, Sessa C, Colombo I. Everything Comes with a Price: The Toxicity Profile of DNA-Damage Response Targeting Agents. Cancers. 2022;14.
- Di Lauro V, Barchiesi G, Martorana F, Zucchini G, Muratore M, Fontanella C, et al. Health-related quality of life in breast cancer patients treated with CDK4/6 inhibitors: a systematic review. ESMO Open. 2022;7.
- Vitale SR, Martorana F, Stella S, Motta G, Inzerilli N, Massimino M, et al. PI3K inhibition in breast cancer: Identifying and overcoming different flavors of resistance. Critical Reviews in Oncology/Hematology. 2021;162.
- Tirrò E, Massimino M, Romano C, Martorana F, Pennisi MS, Stella S, et al. Prognostic and Therapeutic Roles of the Insulin Growth Factor System in Glioblastoma. Frontiers in Oncology. 2021;10.
- Stella S, Vitale SR, Massimino M, Puma A, Tomarchio C, Pennisi MS, et al. A novel system for semiautomatic sample processing in chronic myeloid leukaemia: Increasing throughput without impacting on molecular monitoring at time of sars-cov-2 pandemic. Diagnostics. 2021;11.
- Stella S, Martorana F, Manzella L, Vigneri P. The other side of the coin: dissecting molecular mechanisms behind hereditary breast cancer in search of therapeutic opportunities. Translational Oncology. 2021;14.
- Romano C, Martorana F, Pennisi MS, Stella S, Massimino M, Tirrò E, et al. Opportunities and challenges of liquid biopsy in thyroid cancer. International Journal of Molecular Sciences. 2021;22.
- Pavone G, Motta L, Martorana F, Motta G, Vigneri P. A new kid on the block: Sacituzumab govitecan for the treatment of breast cancer and other solid tumors. Molecules. 2021;26.
- Martorana F, Motta G, Pavone G, Motta L, Stella S, Vitale SR, et al. AKT Inhibitors: New Weapons in the Fight Against Breast Cancer? Frontiers in Pharmacology. 2021;12.
- Martorana F, Colombo I, Treglia G, Gillessen S, Stathis A. A systematic review of phase II trials exploring anti-PD-1/PD-L1 combinations in patients with solid tumors. Cancer Treatment Reviews. 2021;101.
- Manganaro L, Nicolino GM, Dolciami M, Martorana F, Stathis A, Colombo I, et al. Radiomics in cervical and endometrial cancer. British Journal of Radiology. 2021;94.
- Genta S, Martorana F, Stathis A, Colombo I. Targeting the DNA damage response: PARP inhibitors and new perspectives in the landscape of cancer treatment. Critical Reviews in Oncology/Hematology. 2021;168.
- Di Franco S, Bianca P, Sardina DS, Turdo A, Gaggianesi M, Veschi V, et al. Adipose stem cell niche reprograms the colorectal cancer stem cell metastatic machinery. Nature Communications. 2021;12.
- Colombo I, Genta S, Martorana F, Guidi M, Frattini M, Samartzis EP, et al. Phase I dose-escalation study of the dual PI3K-mTORC1/2 inhibitor gedatolisib in combination with paclitaxel and carboplatin in patients with advanced solid tumors. Clinical Cancer Research. 2021;27:5012-9.
- Strazzanti A, Martorana F, Intagliata E, Lanzafame K, Pavone G, Mauro S, et al. Implications of antidepressants use in breast cancer: A brief review. Surgery, Gastroenterology and Oncology. 2020;25:229-35.
- Milluzzo A, Vigneri P, Martorana F, Vigneri R, Sciacca L. Type 2 diabetes and cancer: problems and suggestions for best patient management. Exploration of Medicine. 2020;1:184-204.
- Tirrò E, Martorana F, Romano C, Vitale SR, Motta G, Di Gregorio S, et al. Molecular alterations in thyroid cancer: From bench to clinical practice. Genes. 2019;10.
- Martorana F, Vigneri P, Manzella L, Tirrò E, Soto Parra HJ. Delayed use of eribulin in a heavily pretreated liposarcoma patient, previously misdiagnosed as leiomyosarcoma. Future Oncology. 2019;16:9-13.
- Manzella L, Massimino M, Stella S, Tirrò E, Pennisi MS, Martorana F, et al. Activation of the IGF axis in thyroid cancer: Implications for tumorigenesis and treatment. International Journal of Molecular Sciences. 2019;20.
- Gerratana L, Basile D, Buono G, De Placido S, Giuliano M, Minichillo S, et al. Androgen receptor in triple negative breast cancer: A potential target for the targetless subtype. Cancer Treatment Reviews. 2018;68:102-10.
- Vigneri P, Martorana F, Manzella L, Stella S. Biomarkers and prognostic factors for malignant pleural mesothelioma. Future Oncology. 2015;11:29-33.